Simparica Trio Chewable Tablets for Dogs 6 Month Supply

• DESCRIPTION:Simparica Trio Chewable Tablets for Dogs are used to prevent Dirofilaria immitis-related heartworm disease in dogs. It also treats and controls roundworms, adult hookworms, and ticks, kills adult fleas, and prevents and treats flea infestations.

  Key Benefits: Simparica Trio contains:

  • Sarolaner, an insecticide and acaricide that blocks glutamate-gated and GABA chloride channels in the acarine and insect nervous system. This causes increased stimulation of the nerves, then parasite death.
  • Selamectin works to paralyze and/or kill a broad range of parasites (invertebrates) by interfering with the conductance of their chloride channels.
  • This disrupts normal transmission, inhibiting nerve cell electrical activity of nematodes and muscle cells of arthropods. This causes paralysis and/or death of the parasite.
  • Pyrantel Pamoate, a tetrahydropyrimidine nematocide that depolarized and blocks the neuromuscular transmission of susceptible parasites, leading to paralysis and death or elimination.
  • Moxidectin, a macrocyclic lactone endectocide that interferes with the parasite’s chloride channel-mediated neurotransmission, causing paralysis and parasite death.

    Formulated For: For dogs and puppies 8 weeks or older and weigh 2.8 lbs or more.

    How is Medication Given? Dosage Recommendations:

  • Dogs 2.8 to 5.5 Pounds: One Tablet Containing 12.5 mg Pyrantel, 0.06 mg Moxidectin, and 3 mg Sarolaner
  • Dogs 5.5 to 11 Pounds: One Tablet Containing 25 mg Pyrantel, 0.12 mg Moxidectin, and 6 mg Sarolaner
  • Dogs 11 to 22 Pounds: One Tablet Containing 50 mg Pyrantel, 0.24 mg Moxidectin, and 12 mg Sarolaner
  • Dogs 22 to 44 Pounds: One Tablet Containing 100 mg Pyrantel, 0.48 mg Moxidectin, and 24 mg Sarolaner
  • Dogs 44 to 88 Pounds: One Tablet Containing 200 mg Pyrantel, 0.96 mg Moxidectin, and 48 mg Sarolaner
  • Dogs 88 to 132 Pounds: One Tablet Containing 300 mg Pyrantel, 1.44 mg Moxidectin, and 72 mg Sarolaner
  • Feed without or with food.
  • Ensure that your dog has consumed his or her full dose and that no part is refused or lost.
  • If you miss a monthly dose, administer right away and resume the monthly schedule.
  • Administer orally once monthly.
  • If your dog is currently infested with ticks, he or she should be evaluated before treatment to identify the tick species.
  • Recommended dosage rate is 0.54 mg of Sarolaner per pound of body weight, 2.27 mg per pound of pyrantel (pamoate), and 0.011 mg per pound of moxidectin.

    What Results Can I Expect? Simparica Trio: Controls and treats adult hookworm and roundworm infections. Prevents and treats flea infestations. Controls and treats ticks (American dog, brown dog, Gulf Coast, black-legged, and lone star). Prevents heartworm disease.

    What Form Does Medication Come In? Chewable Tablet

    Dose and Administration: Sold as a 6-month (6-dose), weight-based supply.

    Possible Side Effects: Potential adverse reactions include:

  • Polydipsia
  • Hyperactivity
  • Polyuria
  • Anorexia
  • Lethargy
  • Diarrhea
  • Vomiting Simparica Trio contains Sarolaner, an isoxazoline drug. This drug class is associated with certain neurological effects, including:
  • Seizures
  • Ataxia
  • Tremors
    These effects are possible whether or not the dog has a history of a neurological condition. Administer cautiously to a dog with a known neurological disorder.

    Precautions: Not effective against D. immitis in the adult stage. Before use, dogs should receive a heartworm test to rule out an existing infection. Dogs with heartworm infections will require treatment, as determined by a veterinarian, to remove the adult worms. Not proven safe for use in lactating, pregnant, or breeding dogs. Keep out of reach of animals and children. Never administer to a human.

    Storage Recommendations: Store in a cool and dry location between 59 degrees – 86 degrees F (15-30 degrees C).

    In Case of Overdose: Call your nearest emergency pet hospital.

Active Ingredients: Pyrantel , Moxidectin and Sarolaner.

Main Ingredients: Simparica Trio is named for its trio of active ingredients – Pyrantel, Moxidectin, and Sarolaner.